Enzymes technologiesEnzyme Technologies
Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications, by Yang, Hsiu-Chiung / Yeh, Wu-Kuang / McCarthy, J. R.

Highlighting the critical importance of enzymes in pharmaceutical and biotechnology research, Enzyme Technologies presents thorough discussions on chemical biology of enzymes, redesigning binding and catalytic specificities of enzymes, and applications of enzymes to biotechnology research in the post-genomic era.

This timely review presents researchers, students, and faculty with expert reviews of recent progress in comprehending molecular mechanisms of biosynthetic and biocatalytic processes as well as how to utilize that knowledge for practical applications.

From the contents

A. Enzymes - essential workhorses in pharmaceutical research
1. Assay Technologies for Proteases
Anuradha Roy,Gerald H. Lushington, James McGee, Rathnam Chaguturu
2. Discovery and development of isozyme-selective inhibitors involved in lipid metabolism
Taichi Ohshiro, Hiroshi Tomoda
3. Covalent enzyme inhibitor in drug discovery and development
Shujaath Mehdi
4. Preclinomics: Using Enzyme Assays and Rodent Models for Metabolic diseases
Wu-Kuang Yeh, Richard G. Peterson
B. Enzymes - indispensable tools for improving druggability
5. Enzymes and Targeted Activation of Prodrugs
Yanhui Yang, Yu Chen, Herve Aloysius, Daigo Inoyama, Longqin Hu
6. Evolution of an Orally Active Prodrug of Gemcitabine
James R. McCarthy
7. Enzymatically Activated Phosphate and Phosphonate Prodrugs
Ivan S. Krylov, Charles E. McKenna
C. Enzymes - powerful weapons for correcting Nature's errors
8. Treatment options for mucopolysaccharidosis type II (Hunter's symdrome)
Michael Beck
9. Enzyme replacement therapy for Fabry disease
Ley Nadine Lacbawan, Wei Zheng,Ozlem Goker-Alpan
10. Methods and principles of pancreatic function tests
Henrike von
1. Edition February 2014
129.- Euro
2014. 356 Pages, Hardcover
ISBN 978-0-470-28626-5 - John Wiley & Sons