Evaluation of Enzyme Inhibitors in Drug Discovery
A Guide for Medicinal Chemists and Pharmacologists, by Copeland, Robert A.

With enzymes being the most valued and common of drug targets, an understanding of their interactions with inhibitors is critical to successful drug discovery.

Now in a second edition, this proven work clearly explains the biochemical data and experimental details underlying the science, arming medicinal chemists and pharmacologists with the tools they need to master the art of applied enzymology for drug discovery.

Bio Base Europe is the Europe's first open innovation and education centre for the biobased economy.

Flanders and The Netherlands have joined forces to build state-of-the-art research and training facilities to speed up the economic growth, innovation capacity, and sustainable development of our society.

Bio Base Europe consists of the Bio Base Europe Pilot Plant and the Bio Base Europe Training Centre.

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Peroxicats [peroxidases as biocatalysts]. Novel and more robust fungal peroxidases as industrial biocatalysts.

[This article is based on the presentation of the Peroxicats FP7 project. Grant agreement nº: KBBE-2010-4-265397. Total budget: 4.3 million €; EC-funding: 3 million €]

Enzymes catalyzing redox reactions (oxidoreductases) represent an environmentally friendly alternative to harsh chemicals in industrial processes that include oxidative transformations for production of chemicals and other value-added products with large markets in developed and emerging economies.

Fungi and other microorganisms provide the wider and more easily exploitable source for oxidative enzymes.

However, the penetration of microbial oxidoreductases in the chemical markets is still low despite the recent discovery of very promising enzymes.